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Tadalafil dosage 40 mg (2.0 mg/kg) and dronabinol dosage 8 mg (1.8 mg/kg) daily for 11-15 days with and without maintenance dosage. Additionally, patients receiving this dosage-intense regimen during a 12-day period with placebo twice daily were also randomized to 1 month of treatment dronabinol at dosage 40 or 80 mg daily (0.4 mg/kg) or placebo.
Outcome Measures
Subjective responses to the rating scale used assess psychological and medical symptoms.
Results
Of the 56 patients who completed study, 44 were receiving placebo and 11 patients were receiving a 40 mg dose of dronabinol and 11 patients were receiving a 80 mg dose of dronabinol. Patients randomized to dronabinol were significantly more likely to experience improvement, with increases in all five subjective measures (positive, negative, general health, vitality, and sleepiness or drowsiness) compared to placebo. There was also statistically significant difference between the groups in overall response rates for both the positive and tadalafil 10mg dosage negative symptom scales. This difference was maintained when patients were stratified according to patient age, sex, and body mass index (BMI).
Conclusion
In a pharmacological study with high placebo response rate, dronabinol was found to be safe and effective for the treatment of anxiety in patients with BPD. These results may be of considerable significance to the treatment of anxiety in general and for BPD particular as anxiety in is a commonly reported symptom (1). The authors conclude that clinical data suggest dronabinol is well tolerated and could be recommended for the management of anxiety and related dysfunction in patients with BPD.
1. Bhasin S, Beasley T. Treatment of anxiety disorders: a review. J Clin Psychiatry. 2010 Oct;70(10):1065-75.
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